Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-2-carboxylate
2-Methoxycarbonylindole-5-boronic acid
CAS: 284660-86-2
Molecular Formula: C10H10BNO4
Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-2-carboxylate - Names and Identifiers
Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-2-carboxylate - Physico-chemical Properties
| Molecular Formula | C10H10BNO4 |
| Molar Mass | 219 |
| Density | 1.39±0.1 g/cm3(Predicted) |
| Boling Point | 484.2±48.0 °C(Predicted) |
| pKa | 8.55±0.30(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Sensitive | IRRITANT |
| MDL | MFCD09751354 |
Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-2-carboxylate - Introduction
Acid is an organic compound with the chemical formula C10H10BNO4. It is an active organoboron reagent with a variety of uses.
Nature:
-Appearance: White solid
-Melting point: about 160-165°C
-Solubility: Soluble in many organic solvents, such as methanol, ethanol and dimethyl amide
Use:
-Drug research: acid can be used as a drug intermediate to synthesize indole derivatives. These derivatives have a wide range of applications in medicinal chemistry, such as anti-tumor, anti-inflammatory and anti-viral.
-organic synthesis: it is often used as a ligand for metal-catalyzed reactions, and can participate in Suzuki coupling reactions and Buchwald-Hartwig coupling reactions catalyzed by Pd, Ni and other metals.
-Materials Science: It has application potential in the field of organic electronic materials, and can be used in the preparation of organic light-emitting diodes (OLED), organic solar cells and other devices.
Preparation Method:
A synthesis method of acid is to react 2-methoxycarbonyl indole with triphenylboron fluoride, and then undergo hydrolysis treatment to obtain the product.
Safety Information:
The specific safety information of acid has not been found in the record, so please follow the laboratory's operating procedures and take appropriate safety measures when using it. For laboratory use of this compound, refer to the relevant MSDS (Material Safety Data Sheet) for more detailed safety information.
Nature:
-Appearance: White solid
-Melting point: about 160-165°C
-Solubility: Soluble in many organic solvents, such as methanol, ethanol and dimethyl amide
Use:
-Drug research: acid can be used as a drug intermediate to synthesize indole derivatives. These derivatives have a wide range of applications in medicinal chemistry, such as anti-tumor, anti-inflammatory and anti-viral.
-organic synthesis: it is often used as a ligand for metal-catalyzed reactions, and can participate in Suzuki coupling reactions and Buchwald-Hartwig coupling reactions catalyzed by Pd, Ni and other metals.
-Materials Science: It has application potential in the field of organic electronic materials, and can be used in the preparation of organic light-emitting diodes (OLED), organic solar cells and other devices.
Preparation Method:
A synthesis method of acid is to react 2-methoxycarbonyl indole with triphenylboron fluoride, and then undergo hydrolysis treatment to obtain the product.
Safety Information:
The specific safety information of acid has not been found in the record, so please follow the laboratory's operating procedures and take appropriate safety measures when using it. For laboratory use of this compound, refer to the relevant MSDS (Material Safety Data Sheet) for more detailed safety information.
Last Update：2024-04-09 20:49:11
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